Automated control of inspired oxygen in mechanically ventilated trauma and acute care surgery patients: A randomized controlled trial.
Richard D Branson, Thomas C Blakeman, Laura Moore et al.
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In 30 seconds
This randomized controlled trial evaluated the effectiveness of automated physiologic closed-loop control (PCLC) of inspired oxygen fraction (FIO2) compared to manual control (MC) in mechanically ventilated trauma and acute care surgery patients. The study found that PCLC was noninferior to MC in maintaining target arterial oxygen saturation (SpO2), with a median time within the target range of 30.1% for PCLC versus 36.8% for MC. Additionally, PCLC resulted in fewer hypoxemic events (22% vs. 38%, p=0.04).
Key findings
- Median time within SpO2 target range was 30.1% for PCLC and 36.8% for MC.
- Hypoxemia occurred in 22% of PCLC patients compared to 38% in MC patients (p=0.04).
- PCLC led to lower FIO2 exposure and more frequent automated adjustments.
- Fewer manual FIO2 adjustments were required with PCLC.
Why it matters
The findings suggest that automated control of inspired oxygen can enhance patient safety by reducing hypoxemic events while maintaining adequate oxygen saturation, potentially easing the workload for clinicians managing mechanically ventilated patients.