Association between fluid balance and weaning outcomes in patients with mechanical ventilation: a systematic review and meta-analysis.
Jian Ke, Juan Deng, Xiaoyu Yang et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the relationship between fluid balance and weaning outcomes in patients on mechanical ventilation, analyzing 26 studies with 13,665 patients. The results indicated that a more positive 24-hour pre-weaning fluid balance was linked to a higher risk of weaning failure, with an odds ratio of 2.28 (95% CI: 1.89 to 2.74, P < 0.001).
Key findings
- A more positive 24-hour pre-weaning fluid balance increased the risk of weaning failure (OR = 2.28, 95% CI: 1.89 to 2.74, P < 0.001).
- Cumulative fluid balance was associated with weaning outcomes (WMD = -823.45 mL, 95% CI: -1189.65 to -457.25, P < 0.001).
- The study included 26 observational studies with a total of 13,665 patients.
Why it matters
Understanding the impact of fluid balance on weaning outcomes can help clinicians identify patients at higher risk for weaning failure, potentially guiding monitoring and management strategies during the weaning process.
What to keep in mind
The findings are based on observational studies, which may introduce substantial heterogeneity and potential residual confounding.