Hyalinizing Clear Cell Carcinoma of the Lung With Uncommon Distant Cutaneous Metastasis and Aggressive Clinical Course.
David M Gustafson, Sansar Tiwari, Catherine G Chung
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Case in brief
A patient presented with primary lung hyalinizing clear cell carcinoma (PLHCCC) characterized by tumor lobules with pale cytoplasm and a mixed stroma. This case is notable for the occurrence of cutaneous metastasis, which has not been previously reported in PLHCCC. The patient experienced an aggressive clinical course, indicating a poor prognosis.
What made this case unusual
The presence of cutaneous metastasis from primary lung hyalinizing clear cell carcinoma is an atypical finding that has not been documented before.
Diagnostic / clinical pearl
Clinicians should be aware that primary lung hyalinizing clear cell carcinoma can present with cutaneous metastasis, which may indicate a more aggressive disease course.
Why it matters
This case highlights the potential for atypical metastatic behavior in hyalinizing clear cell carcinoma, emphasizing the need for careful monitoring and management.