Fibroblast activation protein-targeted molecular imaging in interstitial lung disease: a systematic review.
Ann Nucl MedMay 7, 2026 (epub)
Ali Ghorbani Olya, Mehrzad Bahtouee, Esmail Jafari et al.
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In 30 seconds
This systematic review evaluates the role of fibroblast activation protein (FAP)-targeted imaging in interstitial lung disease (ILD). Analyzing twelve studies, it was found that FAPI imaging shows elevated tracer uptake in ILD patients, correlating with fibrotic patterns on high-resolution computed tomography (HRCT) and declining lung function. FAPI uptake is associated with active fibrogenesis.
Key findings
- FAPI imaging demonstrated elevated tracer uptake in ILD patients, correlating with fibrotic patterns on HRCT.
- Increased FAPI uptake was significantly associated with declining lung function, including forced vital capacity (FVC) and diffusing capacity of the lung for carbon monoxide (DLCO).
- Histopathological analyses confirmed FAPI uptake corresponds to fibroblast-rich regions, validating its specificity for active fibrogenesis.
Why it matters
FAP-targeted imaging provides a non-invasive method to visualize and quantify active fibrosis in ILD, offering insights into disease activity and functional impairment. This could enhance the understanding of disease progression and inform treatment strategies.