Targeted Nrf2 activation improves vascular endothelial function with aging and prevents vascular dysfunction following disuse in younger and older adults.
Free Radic Biol MedMay 7, 2026 (epub)
Nicholas A Carlini, Brady E Hanson, Bradley A Ruple et al.
✦ AI-curated · Sources linked
In 30 seconds
This randomized controlled trial investigated the effects of PB125, a Nrf2 activator, on vascular endothelial function in 20 younger and 24 older adults. The study found that PB125 significantly improved brachial flow-mediated dilation (FMD) in older adults (2.8% to 3.8%, p < 0.0001) and preserved vascular function during disuse, highlighting its potential benefits in mitigating age-related vascular dysfunction.
Key findings
- PB125 increased brachial FMD in older adults from 2.8% to 3.8%, p < 0.0001.
- In older adults, PB125 preserved brachial FMD during bed rest, p = 0.543.
- PB125 maintained popliteal FMD in younger adults after limb immobilization, p < 0.05.
Why it matters
The study highlights the potential of Nrf2 activation to improve vascular health in aging populations and during periods of physical inactivity, which are critical factors in cardiovascular disease prevention.