CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design and baseline characteristics.
Am Heart JMay 7, 2026 (epub)
Clinical ResearchCardiology
Jeffrey L Anderson, Heidi T May, Tyler Winslow et al.
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In 30 seconds
The CorCal Outcomes trial is a randomized controlled trial comparing the effectiveness of coronary artery calcium (CAC) versus the pooled cohort equation (PCE) for guiding statin therapy in primary prevention patients. Enrolling 5,772 nondiabetic participants, the study aims to assess which method better prevents atherosclerotic cardiovascular disease (ASCVD) events. The trial is ongoing, with a projected completion in mid-2026.
Key findings
- 5,772 patients were enrolled, with 2,886 randomized to each arm.
- 5,329 participants completed necessary testing for primary analysis.
- Average age of participants was 64.3 years, with 51.5% female.
Why it matters
Understanding the comparative effectiveness of CAC and PCE in statin therapy selection could enhance decision-making in primary prevention of ASCVD, potentially leading to better patient outcomes.