Severe familial hypercholesterolemia and pregnancy: handle with care.
Beatrice Dal Pino, Alessandro Ghelardi, Lorenzo Innocenti et al.
✦ AI-curated · Sources linked
Case in brief
This report discusses the management of three women with familial hypercholesterolemia during pregnancy, highlighting the exacerbation of hypercholesterolemia due to physiological changes and the common practice of reducing lipid-lowering therapy. The cases illustrate the necessity for tailored clinical management to mitigate risks associated with maternal hypercholesterolemia and its potential impact on cardiac health.
Diagnostic / clinical pearl
Clinicians should recognize that pregnancy can significantly worsen hypercholesterolemia in women with familial hypercholesterolemia, necessitating careful management of lipid-lowering therapies.
Why it matters
This case underscores the importance of personalized care in managing pregnant patients with familial hypercholesterolemia to prevent adverse cardiovascular outcomes.