Randomized Clinical Trial Comparing Effects of Pulsatile vs Nonpulsatile Cardiopulmonary Bypass on Neurologic Outcomes.
Srihari Rajesh, Kevsergül Dayi, Marc J Lussier et al.
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In 30 seconds
This randomized controlled trial evaluated the effects of pulsatile versus nonpulsatile cardiopulmonary bypass on S100B levels and neurological outcomes in pediatric patients undergoing congenital heart surgery. Among 144 patients, S100B levels were similar across both perfusion modalities, and 36 patients experienced neural injuries, with no significant differences in outcomes related to the type of perfusion used.
Key findings
- S100B levels were similar between pulsatile and nonpulsatile perfusion at all measured time points.
- A total of 36 patients experienced neural injuries, with 15 in the nonpulsatile group and 21 in the pulsatile group.
- S100B levels rose during CPB, peaking before weaning and 1 hour after CPB.
- 24-hour S100B levels showed a weak association with clinical outcomes.
Why it matters
Understanding the impact of different perfusion modalities on neurological outcomes is crucial for optimizing care in pediatric patients undergoing congenital heart surgery. This study suggests that the choice of perfusion may not significantly influence neural injury risk as measured by S100B levels.