Association of remnant cholesterol with cardiovascular disease events in patients with diabetes: a dose-response systematic review and meta-analysis of adjusted models.
Nutr Metab Cardiovasc DisApr 17, 2026 (epub)
Reza Eshraghi, Ashkan Bahrami, Mohammadreza Kosari et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the relationship between remnant cholesterol (RC) levels and cardiovascular disease (CVD) events in individuals with diabetes, analyzing data from 2,276,576 participants across fifteen studies. The findings indicate that higher RC levels are associated with increased cardiovascular events, with a pooled hazard ratio for major adverse cardiovascular events (MACE) of 1.64 (95% CI: 1.16-2.30).
Key findings
- Pooled HR for MACE was 1.64 (95% CI: 1.16-2.30), indicating higher risk with increased RC.
- Pooled HR for revascularization was 1.44 (95% CI: 1.22-1.70).
- Pooled HR for ischemic stroke was 1.12 (95% CI: 1.01-1.24).
- Dose-response analysis showed significant relationships for MACE (p < 0.0001) and myocardial infarction (p = 0.0008).
Why it matters
Understanding the association between remnant cholesterol and cardiovascular events in diabetic patients can enhance risk stratification and inform clinical decision-making regarding lipid management and monitoring.