Mitomycin C in the Endoscopic Treatment of Airway Stenosis: A Systematic Review and a Meta-Analysis.
Ann Otol Rhinol LaryngolMay 13, 2026 (epub)
Elena Russo, Giuseppe Mangiameli, Andrea Costantino et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the efficacy of adjuvant mitomycin C (MMC) in the endoscopic treatment of airway stenosis, involving 358 patients with a median age of 48 years. The study found a cumulative stenosis resolution rate of 76.37%, but current evidence does not support definitive conclusions on MMC's effectiveness in reducing recurrence or prolonging intervention-free intervals.
Key findings
- Cumulative stenosis resolution rate was 76.37% (n=187/254).
- 52.33% of patients required multiple endoscopic procedures (n=131/260).
- Only 4.08% of patients required other surgical treatments (n=26/310).
- Median intervention-free interval was 366 days (n=155/358).
Why it matters
Understanding the effectiveness of adjuvant treatments like MMC in airway stenosis is crucial for optimizing patient management and improving outcomes. This study highlights the need for further research to establish clear guidelines.