Type, severity, frequency and management of adverse reactions associated with ultrasound contrast agents: a systematic review and meta-analysis.
Eur RadiolMay 15, 2026 (epub)
Honoria Ocagli, Laura Romanini, Adea Llane et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the incidence of adverse drug reactions (ADRs) associated with ultrasound contrast agents (UCAs) in over 1 million adults and 36,000 children. The study found severe acute ADRs to be very rare, occurring at rates of 6 and 16 cases per 100,000 in adults and children, respectively. No significant safety differences were noted among UCA products.
Key findings
- Severe acute ADRs occurred at rates of 6 per 100,000 in adults and 16 per 100,000 in children.
- Non-severe acute ADRs were reported in 11 cases per 10,000 adults and 8 cases per 10,000 children.
- Delayed reactions were very rare, with less than 1 case per million in adults.
- No ADRs were reported in pregnant women.
Why it matters
Understanding the safety profile of ultrasound contrast agents is crucial for clinicians, as it informs risk assessment and management strategies in diverse patient populations, including those with cardiovascular disease and pregnant women.