Reduced antihypertensive treatment with maintained ambulatory blood pressure control following weight loss in type 2 diabetes.

In 30 seconds

This single-arm intervention trial studied 32 adults with type 2 diabetes and hypertension undergoing a dietary weight-loss program. After 12 months, the median number of antihypertensive medications decreased from 2 to 1 (p = 0.004), while office and ambulatory blood pressure remained stable despite reduced medication use.

Key findings

• Mean weight loss at 12 months was 11.6 ± 6.0 kg.
• The median number of antihypertensive medications decreased from 2 to 1 (p = 0.004).
• Antihypertensive treatment use decreased from 88% to 59%.
• Night-time systolic blood pressure variability decreased (p < 0.05).

Why it matters

This study highlights the potential for weight loss to reduce the need for antihypertensive medications in patients with type 2 diabetes, while maintaining stable blood pressure control, which may inform treatment strategies in this population.