Association of the angiotensin II type 1 receptor A1166C polymorphism with essential hypertension in the Chinese population: a meta-analysis with ethnic and geographic subgroup analyses.
Blood PressJun 1, 2026 (epub)
Jun Gu, Li Shi, Weidong Ren et al.
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In 30 seconds
This meta-analysis examined the association between the AT1R A1166C polymorphism and essential hypertension (EH) in the Chinese population, analyzing data from 17 studies with 9,213 patients and 4,494 controls. The study found that the AC/CC genotype (OR = 1.34) and C allele (OR = 1.44) were associated with increased EH risk, particularly in Han and Yi ethnic groups.
Key findings
- AC/CC genotype associated with increased EH risk (OR = 1.34, 95% CI: 1.07-1.69, p = 0.01).
- C allele linked to higher EH risk (OR = 1.44, 95% CI: 1.14-1.82, p = 0.002).
- Stronger associations observed in Han (AC/CC: OR = 1.56) and Yi (AC/CC: OR = 1.80) populations.
- C allele significantly associated with EH in northern/northwestern regions (OR = 1.37, p = 0.04).
Why it matters
Understanding genetic factors contributing to essential hypertension can aid in identifying high-risk populations. This knowledge may inform early screening and targeted preventive strategies, enhancing patient care and management of hypertension.