Phase-resolved functional lung MRI detects single-dose and sustained bronchodilator responses in COPD in a randomized crossover trial.
Eur RadiolMay 20, 2026 (epub)
Andreas Voskrebenzev, Till F Kaireit, Marius M Klein et al.
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In 30 seconds
This randomized controlled trial evaluated the effects of tiotropium/olodaterol on phase-resolved functional lung MRI parameters in 32 patients with moderate-to-severe COPD. The study found significant improvements in ventilation and perfusion metrics after a single dose, with a decrease in pulmonary pulse wave velocity after multiple doses, indicating effective bronchodilator response.
Key findings
- FVL-CM improved by 4.1 percentage points after single-dose T/O compared to placebo.
- QN increased by 0.4 percentage points following single-dose T/O treatment.
- PWV decreased by -0.87 m/s after multiple doses of T/O.
- Significant correlations were found between PREFUL MRI parameters and pulmonary function tests.
Why it matters
The findings highlight the potential of PREFUL MRI as a sensitive, non-invasive tool for assessing bronchodilator responses in COPD, which could enhance monitoring and management of the disease.