Temporal shifts in antiretroviral therapy regimens and metabolic outcomes in people living with HIV: A systematic review and meta-analysis.
Melani Ratih Mahanani, Myo Chit, Sophie Mohr et al.
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In 30 seconds
This systematic review and meta-analysis evaluated metabolic outcomes associated with antiretroviral therapy (ART) in adults living with HIV. Analyzing data from 39 studies involving 24,632 participants, the study found that ART-treated individuals had higher odds of metabolic syndrome (OR = 2.16, 95% CI = 1.33-3.52) compared to ART-naïve individuals, while no significant association was found for type 2 diabetes mellitus.
Key findings
- ART-treated adults had nearly twice the odds of metabolic syndrome compared to ART-naïve adults (OR = 2.16, 95% CI = 1.33-3.52).
- No statistically significant association was observed between ART use and type 2 diabetes mellitus (OR = 1.37, 95% CI = 0.65-2.90).
- The metabolic burden associated with HIV treatment has shifted from lipid abnormalities to weight- and glucose-related outcomes.
Why it matters
Understanding the metabolic risks associated with different ART regimens is crucial for managing long-term health in people living with HIV, as these risks can significantly impact overall morbidity and quality of life.
What to keep in mind
Findings may be influenced by confounding factors such as disease stage, healthcare access, and survivorship bias.