Progression of persistent atrial fibrillation and impact of ablation: A systematic review and meta-analysis.
Heart RhythmMay 21, 2026 (epub)
Clinical ResearchCardiology
Udit Thakur, Souvik Kumar Das, Nitesh Nerlekar et al.
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In 30 seconds
This systematic review and meta-analysis examined the progression of persistent atrial fibrillation (PsAF) to permanent atrial fibrillation (AF) in various populations. The study found a pooled progression rate of 16.42 per 100 person-years. Contemporary studies indicated lower progression rates compared to earlier cohorts, highlighting the impact of prior pulmonary vein isolation on reducing progression.
Key findings
- The pooled progression rate from PsAF to permanent AF was 16.42 per 100 person-years.
- Contemporary studies showed a progression rate of 11.06 per 100 person-years compared to 21.83 in earlier cohorts.
- Higher prevalence of prior pulmonary vein isolation was associated with a lower progression rate (rate ratio 0.82).
- Catheter ablation utilization remains relatively low despite increasing availability.
Why it matters
Understanding the progression of PsAF to permanent AF is crucial for developing effective management strategies. Identifying predictors of progression can help clinicians tailor interventions and improve patient outcomes.