A systematic review and meta-analysis of elevated lipoprotein(a) and adverse limb outcomes in peripheral artery disease after revascularization.
Bibombe P Mwipatayi, James Dodd, Amirul H Ahmad Bazlee et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the relationship between elevated lipoprotein(a) [Lp(a)] levels and peripheral artery disease (PAD) outcomes post-revascularization. Analyzing data from 10 observational studies with 5794 participants, the study found that elevated Lp(a) was associated with a higher prevalence of PAD (pooled OR, 1.81) and significantly increased risks of adverse limb outcomes, including repeat revascularization (OR, 3.22) and major amputation (OR, 2.62).
Key findings
- Elevated Lp(a) was associated with a greater prevalence of PAD (pooled OR, 1.81).
- Patients with PAD had higher Lp(a) concentrations than controls (mean difference, 21.8 mg/dL).
- Elevated Lp(a) was linked to repeat target-lesion revascularization (OR, 3.22).
- Major adverse limb events were associated with elevated Lp(a) (OR, 5.09).
Why it matters
Understanding the role of elevated Lp(a) in PAD can help clinicians identify patients at higher risk for adverse limb outcomes after revascularization, potentially guiding monitoring and management strategies.