Pre-perfusion coronary wedge pressure and microvascular obstruction in anterior ST elevation myocardial infarction (STEMI): An analysis from the EUROICE study.
Int J CardiolMay 22, 2026 (epub)
Clinical ResearchCardiology
Haroun Butt, Konrad van Beek, Uzma Sajjad et al.
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In 30 seconds
This randomized controlled trial analyzed the relationship between pre-reperfusion coronary wedge pressure (CWP) and microvascular obstruction (MVO) in 82 anterior STEMI patients treated with selective intracoronary hypothermia. The study found that lower CWP and coronary flow pressure index (CFPI) were significantly associated with the presence and extent of MVO, with adjusted odds ratios of 0.91 for both per unit increase in CWP and CFPI.
Key findings
- MVO was present in 64% of patients, with a mean extent of 2.7 ± 4.6% of LV mass.
- Lower CFPI was associated with MVO presence (adjusted OR 0.91 per 0.01 increase, p = 0.002).
- Lower mean CWP was also linked to MVO presence (adjusted OR 0.91 per 1 mmHg increase, p = 0.003).
- CFPI and mean CWP both showed moderate discrimination for MVO, with AUCs of 0.74.
Why it matters
Understanding the relationship between pre-reperfusion indices like CWP and MVO can enhance risk stratification in STEMI patients, potentially guiding therapeutic decisions and improving outcomes.