Fulminant community-acquired pneumonia due to exoU-positive Pseudomonas aeruginosa sequence type 319: A case report and literature review.
Yuji Nishihara, Mutsuka Kurihara, Naoki Okawa et al.
✦ AI-curated · Sources linked
Case in brief
A 65-year-old woman presented with fulminant community-acquired pneumonia caused by Pseudomonas aeruginosa. Despite immediate antimicrobial treatment, she succumbed on the day of admission. Genomic analysis identified the isolate as sequence type 319, which carried the exoU gene, a known virulence factor associated with severe disease outcomes.
What made this case unusual
The case highlights the rapid progression and fatality associated with exoU-positive Pseudomonas aeruginosa, particularly in a patient without known immunodeficiency.
Diagnostic / clinical pearl
Clinicians should be aware that exoU-positive Pseudomonas aeruginosa, particularly sequence type 319, can lead to severe and rapid clinical deterioration.
Why it matters
This case underscores the importance of recognizing the virulence potential of specific Pseudomonas aeruginosa strains, which may inform clinical management and patient prognosis.