Effect of catheter-based renal denervation on orthostatic blood pressure adaptation in patients with uncontrolled hypertension.
J CardiolMay 25, 2026 (epub)
Zhipeng Zhang, Rufeng Shi, Xin Zhang et al.
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In 30 seconds
This randomized controlled trial assessed the impact of catheter-based renal denervation (RDN) on orthostatic blood pressure adaptation in patients with uncontrolled hypertension. At 6 months, the RDN group showed a significant reduction in both supine and standing blood pressure compared to the sham group, with notable differences in orthostatic blood pressure responses.
Key findings
- RDN group had a greater reduction in ambulatory blood pressure compared to sham at 6 months.
- Orthostatic systolic and diastolic blood pressure changes were significantly smaller in the RDN group (p=0.008/0.010).
- Maximum changes in orthostatic blood pressure were also significantly reduced in the RDN group (p=0.041/0.004).
- Orthostatic heart rate changes were similar between RDN and sham groups.
Why it matters
Understanding the effects of renal denervation on blood pressure adaptation during postural changes is crucial for managing patients with uncontrolled hypertension. This study suggests that RDN may improve hemodynamic responses to orthostatic stress.