Nurse Practitioner-Led, Same-Day, Pre-exposure Prophylaxis Delivery Program for People Who Inject Drugs in the United States: Findings From a Pilot Randomized Controlled Trial.
J Assoc Nurses AIDS CareMay 27, 2026 (epub)
Kamal Gautam, Kiran Paudel, Frederick L Altice et al.
✦ AI-curated · Sources linked
In 30 seconds
This pilot randomized controlled trial evaluated a nurse practitioner-led, same-day PrEP delivery model (iRaPID) for HIV prevention among 44 HIV-seronegative people who inject drugs. The study found that 12 of 22 participants filled a PrEP prescription at baseline, with nine doing so on the same day. PrEP uptake at 30 days was significantly higher in the iRaPID group (odds ratio: 5.40).
Key findings
- 12 of 22 participants in the iRaPID group filled a PrEP prescription at baseline.
- PrEP uptake at 30 days was significantly higher in iRaPID with an odds ratio of 5.40.
- Acceptability ratings were high, with mean scores of 3.9 at 30 days and 4.2 at 90 days.
- Only three participants refilled prescriptions at both 30- and 90-day follow-ups.
Why it matters
The study highlights a feasible and acceptable model for increasing PrEP uptake among high-risk populations, addressing a critical gap in HIV prevention strategies. Understanding these dynamics can inform future interventions.