Efficacy and potential mechanisms of alkaloids in animal models for pulmonary fibrosis: a study integrating preclinical systematic review and meta-analysis, network pharmacology and molecular docking.
Int ImmunopharmacolMay 27, 2026 (epub)
Clinical ResearchPulmonology
Hualing Wang, Xinyu Liu, Yi Zeng et al.
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In 30 seconds
This meta-analysis and systematic review evaluated the efficacy of alkaloids in treating pulmonary fibrosis (PF) using data from 35 randomized controlled trials involving 548 animals. The study found that alkaloids significantly improved PF-related indicators compared to controls, highlighting their potential as adjunctive therapy. Key molecular targets identified include AKT1, EGFR, and STAT3.
Key findings
- Alkaloids significantly improved PF-related indicators compared to controls in 35 RCTs.
- Key targets identified include AKT1, EGFR, STAT3, and SRC.
- Molecular docking confirmed stable binding between alkaloids and targets like ALB and MAPK1.
- Alkaloids exert multi-target effects through anti-oxidative and anti-inflammatory mechanisms.
Why it matters
Understanding the mechanisms and efficacy of alkaloids in pulmonary fibrosis can inform future therapeutic strategies. Their potential as adjunctive treatments may enhance patient outcomes in managing this challenging condition.