Hair analysis of formoterol as a novel tool to assess long-term inhalation medication adherence: Data from the TRICOLON trial.
Liz J A Cuperus, A Mireille A Wessels, Huib A M Kerstjens et al.
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In 30 seconds
This randomized controlled trial investigated the use of hair analysis to measure long-term adherence to inhaled formoterol in patients with COPD. Conducted across 10 hospitals in the Netherlands, the study found low intra-patient variability in hair formoterol concentrations (intraclass correlation coefficient .94). However, the correlation between hair concentrations and digital inhaler data was weak.
Key findings
- Low intra-patient variability in hair formoterol concentrations was observed (intraclass correlation coefficient .94).
- A significant correlation between hair formoterol concentration and inhaler use was found only in the segment closest to the scalp (r = .30, p = .039).
- Higher formoterol concentrations were associated with dark hair and lower BMI.
Why it matters
Understanding medication adherence is crucial for effective COPD management. This study explores a novel method for monitoring adherence, which could enhance patient outcomes if validated further.
What to keep in mind
Inter-patient variability and external factors may limit the correlation between hair concentrations and adherence measured by digital inhalers.