First Case of Congenital Toxoplasmosis After Maternal Reinfection in Colombia: Serotyping Evidence of Reinfection by Different Strains.
Sandra Beltrán-Higuera, Lucia Moncada-Roa, Elizabeth Torres-Morales et al.
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Case in brief
An immunocompetent woman with prior Toxoplasma IgG positivity later had both IgG and IgM detected four months before pregnancy. Her child was referred at 17 months with strabismus, bilateral chorioretinitis scars, and elevated anti-Toxoplasma IgG. Serotyping found maternal antibodies to GRA6 types I and III, whereas the child had antibodies only to type I. The authors interpreted this pattern as evidence of maternal reinfection with a different strain around conception, followed by transmission to the child.
What made this case unusual
Serotyping supported reinfection by a different Toxoplasma strain in an immunocompetent mother, with congenital infection despite evidence of prior maternal exposure.
Diagnostic / clinical pearl
Prior maternal Toxoplasma IgG positivity does not exclude congenital infection; in this case, serotyping helped support reinfection with a different strain.