The emerging role of microRNAs as targets of phytochemical intervention in myocardial infarction: a systematic review of in vitro and in vivo studies.
Mirko Marino, Benedetta Mercuriali, Laura Castiglioni et al.
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In 30 seconds
This systematic review examines the role of dietary phytochemicals in modulating microRNA (miRNA) expression in models of myocardial infarction. Analyzing 28 studies, it was found that phytochemicals upregulated 20 miRNAs and downregulated 10, leading to reduced ischemia-induced apoptosis, inflammation, and oxidative stress. The findings suggest potential for phytochemicals in developing new therapeutic strategies for myocardial infarction.
Key findings
- Phytochemicals upregulated 20 miRNAs and downregulated 10 in myocardial infarction models.
- Reduced ischemia-induced apoptosis was associated with decreased cleaved caspase-3 and BAX levels.
- Phytochemicals increased antioxidant enzyme activity, indicating reduced oxidative stress.
- Activation of prosurvival pathways like PI3K/Akt signaling was observed.
Why it matters
Understanding the impact of phytochemicals on miRNA modulation could lead to innovative nutritional and therapeutic strategies for managing myocardial infarction, potentially improving patient outcomes.
What to keep in mind
All included studies were conducted in preclinical models, necessitating clinical trials to confirm findings in humans.