Molecular epidemiology of Pseudomonas aeruginosa in Africa: A systematic review and Meta-analysis.
Nana Serwaa Osei-Kuffour, Francisca Duah, Frederick Kungu et al.
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In 30 seconds
This systematic review and meta-analysis examined the clonal diversity and antimicrobial resistance of Pseudomonas aeruginosa in Africa, analyzing 28 studies from 13 countries. The pooled resistance rate across all antibiotic classes was 54.4%, with 100% resistance observed for tetracyclines and glycylcyclines. High-risk clones (HRCs) accounted for 32.46% of cases.
Key findings
- The pooled resistance rate of Pseudomonas aeruginosa was 54.4% across all antibiotic classes.
- Resistance reached 100% for tetracyclines and glycylcyclines.
- High-risk clones constituted 32.46% of the Pseudomonas aeruginosa cases.
- ST244 was the most prevalent high-risk clone at 47.84%.
Why it matters
Understanding the prevalence and resistance patterns of Pseudomonas aeruginosa is crucial for infection control and treatment strategies, particularly in regions with limited genomic surveillance. This knowledge can inform public health initiatives aimed at combating antimicrobial resistance.