Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir.
Antoine Moulignier, Françoise Heran, Francis Lallemand et al.
✦ AI-curated · Sources linked
Case in brief
A patient with well-controlled HIV presented with slowly progressive encephalitis, exhibiting white matter abnormalities and inflammatory cerebrospinal fluid (CSF). Metagenomic sequencing revealed the presence of Human pegivirus (HPgV-1) RNA in both CSF and brain tissue, with no other pathogens identified. The patient responded positively to off-label treatment with sofosbuvir/ledipasvir, leading to clinical improvement and normalization of CSF findings.
Diagnostic / clinical pearl
Detection of HPgV-1 in CSF and brain tissue may indicate its role in encephalitis, particularly in immunocompromised patients.
Why it matters
This case highlights the need for further research into the neurological implications of HPgV-1, expanding the understanding of its potential impact on central nervous system diseases.