Incidental Detection of PSMA Uptake in Lipomatous Hypertrophy of the Interatrial Septum.
Charisma DeSai, Ahmed Ebada Salem, Devaki Shilpa Sudha Surasi
✦ AI-curated · Sources linked
Case in brief
A patient underwent PET/CT with 18F-Piflufolastat to assess for metastatic prostate cancer. Incidental PSMA uptake was noted in the lipomatous hypertrophy of the interatrial septum (LHIS), a benign lesion. Recognizing this finding is crucial to prevent misinterpretation as a malignant cardiac mass, thus avoiding unnecessary interventions.
What made this case unusual
The incidental PSMA uptake in LHIS is noteworthy as it can mimic malignant processes, presenting a diagnostic challenge.
Diagnostic / clinical pearl
Clinicians should be aware that lipomatous hypertrophy of the interatrial septum can show PSMA uptake, which may be mistaken for malignancy on imaging.
Why it matters
Understanding this potential pitfall in PSMA PET/CT interpretation is essential to prevent unnecessary procedures and anxiety for patients.