Pathological Advances and Clinical Management Insights into Primary Pulmonary Myxoid Sarcoma Harboring the Rare EWSR1 :: CREB1 Fusion.

Int J Surg PatholJun 10, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)PulmonologyOncology (Medical)General Surgery

Yifei Liu, Yuying Sun, Qing Zhang

✦ AI-curated · Sources linked

Case in brief

A 64-year-old woman had a primary pulmonary myxoid sarcoma that had been present for 7 years without symptoms. The tumor was resected, and fluorescence in situ hybridization confirmed an EWSR1::CREB1 fusion, supporting the pathological diagnosis. She received no adjuvant therapy and had no evidence of disease 46 months after surgery.

What made this case unusual

The tumor’s prolonged, asymptomatic presence before resection and absence of disease at follow-up after surgery document an indolent course in this patient.

Diagnostic / clinical pearl

In a suspected primary pulmonary myxoid sarcoma, confirmation of the EWSR1::CREB1 fusion by fluorescence in situ hybridization can support the pathological diagnosis.

Source

PubMed · PMID 42267444

Published in Int J Surg Pathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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