Heart Failure Duration, Cardiac Remodeling, Dysfunction, and Hemodynamic Severity in HFpEF and HFmrEF: Insights From REDUCE LAP-HF II.
JACC Heart FailJun 10, 2026 (epub)
Clinical ResearchCardiology
Shunichi Doi, Sho Kazui, Naoyuki Akashi et al.
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In 30 seconds
This randomized controlled trial analyzed the impact of heart failure (HF) duration on cardiac structure and function in 626 patients with HFpEF and HFmrEF. Results indicated that longer HF duration correlated with increased cardiac remodeling and dysfunction, including lower left ventricular global longitudinal strain (16.4% vs 18.4%; P < 0.0001) and higher risk of worsening HF (HR: 1.70; P = 0.006 for >3 years vs <1 year).
Key findings
- Longer HF duration linked to lower left ventricular global longitudinal strain: 16.4% vs 18.4%; P < 0.0001.
- Right ventricular free wall strain decreased with longer duration: 20.8% vs 24.4%; P < 0.0001.
- Increased risk of HF events with longer duration: HR 1.70 for >3 years vs <1 year; P = 0.006.
- Resting pulmonary capillary wedge pressure elevation more common with longer duration: 75.8% vs 64.9%; P = 0.024.
Why it matters
Understanding the relationship between heart failure duration and cardiac remodeling can help clinicians identify patients at higher risk for worsening heart failure, emphasizing the importance of early diagnosis and intervention.