Factors associated with aortic valve calcification in type 2 diabetes-a Steno INTEN-CT substudy.
Eur Heart J Cardiovasc ImagingSep 1, 2026
Amal Haujir, Preman Kumarathurai, Jacob Volmer Stidsen et al.
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In 30 seconds
This cross-sectional substudy of the Steno INTEN-CT trial examined factors linked to aortic valve calcification (AVC) in 4570 individuals with type 2 diabetes (T2D) aged 55-74. The study found that 46% had AVC > 0, with older age, higher BMI, hypertension, chronic kidney disease, and statin use associated with increased AVC.
Key findings
- 46% of participants had AVC > 0.
- Age was associated with higher AVC (OR per SD 1.54, 95% CI 1.43-1.66).
- Statin use was linked to higher AVC (OR 1.50, 95% CI 1.27-1.78).
- Higher LDL cholesterol had a stronger association with AVC in men (OR 1.39) than in women (OR 1.16).
Why it matters
Understanding the factors associated with AVC in T2D patients can help clinicians identify at-risk individuals and potentially guide monitoring and management strategies to mitigate cardiovascular risks.