Comparative outcomes of balloon-expandable and self-expanding valves in transcatheter aortic valve replacement: A systematic review and meta-analysis.
J CardiolJun 17, 2026 (epub)
Abdelrahman Hafez, Ahmed Sobhy, Ahmed Elshahat et al.
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In 30 seconds
This systematic review and meta-analysis compared balloon-expandable valves (BEVs) and self-expanding valves (SEVs) in adults with severe aortic stenosis undergoing transfemoral TAVR. The analysis included 53 studies with 157,921 participants. BEVs demonstrated significant early survival benefits at 1 month (RR = 0.75) and 6 months (RR = 0.33), along with lower rates of permanent pacemaker implantation.
Key findings
- BEVs showed a 25% reduction in all-cause mortality at 1 month (RR = 0.75).
- At 6 months, BEVs had a 67% lower risk of mortality (RR = 0.33).
- Permanent pacemaker implantation rates were lower with BEVs (RR = 0.75 at 1 month).
- SEVs exhibited superior hemodynamics with lower mean gradients (MD = -3.16 to -7.77 mmHg).
Why it matters
Understanding the comparative outcomes of BEVs and SEVs is crucial for clinicians to make informed decisions regarding transcatheter aortic valve replacement, particularly in tailoring valve selection to optimize patient outcomes.