A GRADE-assessed systematic review and meta-analysis of randomized controlled trials evaluating the effects of olive leaf or olive pomace supplementation on cardiometabolic and anthropometric health markers.
Nutr Metab Cardiovasc DisJun 6, 2026 (epub)
Fatemeh Mansouri, Mahnaz Mardani, Chiara Rucci et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of olive leaf (OL) and olive pomace (OP) supplementation on cardiometabolic health in 1726 participants across 30 randomized controlled trials. OL supplementation significantly improved lipid parameters and reduced inflammatory markers, blood pressure, body weight, and BMI, while OP showed no consistent benefits. The evidence quality varied from very low to high.
Key findings
- OL supplementation improved total cholesterol, triglycerides, LDL-C, ApoB, and oxLDL.
- OL reduced TNF-α, systolic and diastolic blood pressure, body weight, and BMI.
- No significant effects were observed on glycemic markers with OL or OP.
- OP supplementation was associated with an increase in IL-8.
Why it matters
Understanding the impact of dietary supplements like olive leaf on cardiometabolic health can guide clinicians in recommending adjunctive strategies for managing risk factors associated with cardiovascular diseases.