Thyroid-joint crosstalk: a systematic review and meta-analysis of thyroid autoimmunity and dysfunction in juvenile idiopathic arthritis.
J Clin Endocrinol MetabSep 16, 2026
Ilaria Liguoro, Mariabeatrice D'Agostini, Francesca Franco et al.
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In 30 seconds
This systematic review and meta-analysis examined the prevalence of thyroid autoantibody positivity and dysfunction in 19,015 children with juvenile idiopathic arthritis (JIA). The study found a pooled prevalence of 4% for both thyroid autoantibody positivity and thyroid dysfunction. The risk difference for thyroid autoantibody positivity between children with JIA and controls was 0.08.
Key findings
- Pooled prevalence of antithyroid antibody positivity in JIA was 0.04 (95% CI: 0.03-0.05).
- Pooled prevalence of thyroid dysfunction in JIA was also 0.04 (95% CI: 0.03-0.08).
- Family history of thyroid autoimmune disease was associated with an odds ratio of 3.91 (95% CI 1.86-8.25).
- Older age at JIA onset was linked to a mean difference of 2.10 years (95% CI 1.32-2.89).
Why it matters
Understanding the prevalence of thyroid autoimmunity in children with JIA is crucial for early detection and management of potential thyroid dysfunction, which can impact overall health and treatment outcomes.