Computed tomography-derived low muscle status and clinical outcomes after isolated coronary artery bypass grafting: A systematic review and meta-analysis with implications for perioperative nutrition risk stratification.
Nutr HealthJun 17, 2026 (epub)
Ziqiang Zhou, Tingting Sun, Jiangang Zhao et al.
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In 30 seconds
This systematic review and meta-analysis examined the relationship between preoperative CT-derived low muscle status and clinical outcomes in 3931 adults undergoing isolated coronary artery bypass grafting (CABG). The analysis found a pooled hazard ratio of 2.71 for long-term mortality, indicating a potential association, though the evidence was exploratory and highly uncertain.
Key findings
- Pooled hazard ratio for long-term mortality was 2.71, indicating an unfavorable association with low muscle status.
- Three cohorts contributed adjusted estimates for long-term mortality, totaling 3452 participants.
- The analysis revealed high heterogeneity (I² = 92.3%) among studies.
- Secondary outcomes were too heterogeneous for quantitative pooling.
Why it matters
Understanding the prognostic value of low muscle status may help identify patients at higher risk for adverse outcomes after CABG, potentially guiding perioperative nutritional interventions and risk stratification.