Remimazolam for sedation in flexible bronchoscopy: A systematic review and meta-analysis of randomised controlled trials.
PulmonologyJun 18, 2026 (epub)
Maria João Lúcio, Sara Ferreira, Maria Pereira et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the efficacy and safety of remimazolam for sedation in 2,243 adults undergoing flexible bronchoscopy. The study found that remimazolam improved procedural success compared to other sedatives (RR = 1.10; p = 0.02) and significantly reduced the risk of respiratory depression, hypoxaemia, hypotension, and bradycardia.
Key findings
- Remimazolam increased procedural success compared to overall sedatives (RR = 1.10; p = 0.02).
- It significantly reduced the risk of respiratory depression (RR = 0.42; p = 0.0007).
- Remimazolam showed a faster onset compared to dexmedetomidine (MD = -2.16 min; p < 0.00001).
- It had lower rates of hypotension and hypoxaemia compared to propofol.
Why it matters
The findings suggest that remimazolam may enhance safety and efficacy in procedural sedation for bronchoscopy, potentially leading to better patient outcomes and reduced complications during procedures.