Endometriosis and cardiovascular disease risk: a meta-analysis of cohort studies.
Ann MedJun 19, 2026 (epub)
Liaoyao Wang, Yuejie Lu, Hejing Pan et al.
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In 30 seconds
This meta-analysis evaluated the association between endometriosis and cardiovascular disease risk, analyzing data from 11 cohort studies with 3,100,610 participants. The study found that endometriosis is associated with a 22% increased risk of all-cause cardiovascular disease (HR = 1.22; 95% CI: 1.08-1.38), with significant geographic disparities in risk.
Key findings
- Endometriosis is linked to a 22% increased risk of all-cause cardiovascular disease (HR = 1.22; 95% CI: 1.08-1.38).
- Myocardial infarction risk is elevated (HR = 1.29; 95% CI: 1.10-1.50).
- Coronary artery disease risk shows a significant increase (HR = 1.47; 95% CI: 1.29-1.67).
- Higher cardiovascular risks are observed in Asian (HR = 1.36; 95% CI: 1.25-1.48) and North American cohorts (HR = 1.37; 95% CI: 1.16-1.61).
Why it matters
Understanding the increased cardiovascular disease risk in patients with endometriosis is crucial for clinicians, as it highlights the need for proactive cardiovascular monitoring and management in this population, particularly in regions with higher associated risks.