Effects of Weight-Loss Interventions on Kidney, Cardiometabolic and Anthropometric Outcomes in Adults With CKD and Overweight or Obesity: A Systematic Review and Meta-Analysis.
Anastasia Stamatiou, Marieta P Theodorakopoulou, Fotini Iatridi et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of weight-loss interventions on kidney, cardiometabolic, and anthropometric outcomes in overweight or obese adults with chronic kidney disease (CKD). Among 42 studies, bariatric surgery significantly increased estimated glomerular filtration rate (eGFR) by 6.09 mL/min/1.73 m², while incretin-based therapies reduced urine albumin-to-creatinine ratio by 41% compared to placebo.
Key findings
- Bariatric surgery significantly increased eGFR by 6.09 mL/min/1.73 m².
- Incretin-based therapies reduced urine albumin-to-creatinine ratio by 41% compared to placebo.
- Weight-loss interventions improved anthropometric parameters, with a mean weight loss of -4.13 kg.
- Systolic blood pressure showed a non-significant reduction of -3.10 mm Hg following lifestyle interventions.
Why it matters
The findings underscore the potential benefits of weight-loss interventions in managing CKD among overweight or obese patients, particularly regarding kidney function and albuminuria reduction. This highlights the importance of addressing obesity in CKD management.