Cine-derived mitral annular relaxation velocity for detection of preclinical left ventricular diastolic dysfunction.
Magn Reson ImagingJun 25, 2026 (epub)
Clinical ResearchCardiology
Niall McVeigh, David Ryan, Fiona Ryan et al.
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In 30 seconds
This randomized controlled trial evaluated the cine-derived mitral annular relaxation velocity (CMR-MARV) in 236 patients at risk for heart failure. The study found that CMR-MARV correlated significantly with various diastolic strain rates and was independently associated with abnormal left ventricular diastolic dysfunction (ALVDD), achieving an area under the curve (AUC) of 0.76 for detection.
Key findings
- Patients had significantly higher indexed maximal left atrial volume compared to controls (p < 0.001).
- CMR-MARV correlated with radial, circumferential, and longitudinal diastolic strain rates (all p < 0.001).
- A combined model of LAVimax and CMR-MARV achieved excellent discrimination for ALVDD (AUC 0.91, p < 0.0001).
- Independent predictors of ALVDD included LAVimax, CMR-MARV, and peak diastolic longitudinal velocity (all p < 0.001).
Why it matters
The ability to detect preclinical diastolic dysfunction is crucial for early intervention in heart failure. CMR-MARV offers a novel, non-invasive biomarker that enhances diagnostic accuracy and may improve patient outcomes through earlier identification of at-risk individuals.