Kidney failure in patients with ANCA-associated vasculitis: A systematic review of outcomes.
Andreas Kronbichler, Antonio Ramirez de Arellano, Juliette Cattin et al.
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In 30 seconds
This systematic review and meta-analysis examined the cumulative incidence of end-stage kidney disease (ESKD) in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Analyzing data from 49 studies involving 19,301 patients, the findings revealed an ESKD incidence of 14.2% at 1 year and 24.8% at 10 years. Additionally, higher estimated glomerular filtration rate (eGFR) at diagnosis was linked to reduced ESKD risk.
Key findings
- ESKD incidence was 14.2% at 1 year and 24.8% at 10 years of follow-up.
- A 1 mL/min/1.73 m² higher eGFR at diagnosis was associated with a 5-6% reduction in ESKD risk.
- A 1 mL/min/1.73 m² higher eGFR at 6 months post-diagnosis correlated with a 7-8% reduction in ESKD risk.
Why it matters
Understanding the risk of ESKD in AAV patients is crucial for clinicians to identify high-risk individuals and implement timely interventions. Monitoring eGFR can help predict kidney outcomes and guide management strategies.
What to keep in mind
The pooled estimates should be interpreted with caution due to high heterogeneity in patient characteristics across studies.