Lipomatous hamartoma of the semilunar valve exhibits molecular genetic characteristics of lipoma.
Encica Svetlana, Molnar Adrian, Katherine Geiersbach et al.
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Case in brief
A 26-year-old woman presented with a symptomatic pulmonary valve lesion initially suspected to be a papillary fibroelastoma. Surgical intervention revealed a lipomatous hamartoma of the pulmonary valve. Microarray analysis indicated a clonal neoplastic proliferation, resembling that of a classical lipoma, suggesting a need for reevaluation of its classification.
Diagnostic / clinical pearl
Clinicians should consider the possibility of a lipomatous hamartoma as a neoplastic entity rather than a benign malformation when evaluating cardiac valve lesions.
Why it matters
This case highlights the need for further investigation into the pathogenesis and classification of benign adipocytic tumors of the heart, which may have implications for diagnosis and management.