Cardiac arrest in an adolescent following an overdose of antidepressants comprising sertraline, quetiapine fumarate, and lamotrigine: Case report.
Li Zheng, Liaoyun Zhang, Fei Wang et al.
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Case in brief
An 11-year-old with depression ingested large quantities of sertraline (3 g), quetiapine fumarate (5 g), and lamotrigine (3 g). About 4 hours later, the patient developed hypoxemia, hypotension, and persistent seizures, followed by cardiac arrest. The abstract does not report the subsequent clinical course or outcome, so resolution cannot be described.
What made this case unusual
The reported cardiac arrest occurred in an 11-year-old after a combined overdose of three psychotropic medications; the abstract notes that cardiotoxicity had primarily been observed in adults.
Diagnostic / clinical pearl
After a substantial mixed psychotropic overdose in a child, monitor for evolving hypoxemia, hypotension, persistent seizures, and cardiac arrest.