Long-term SBP time in target and risk of cardiovascular events in older adults: a secondary analysis of the ASPREE cohort.
Michael E Ernst, Katherine L Webb, Raj C Shah et al.
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In 30 seconds
This observational study analyzed data from the ASPREE cohort of 16,730 older adults (mean age 74) to assess the relationship between systolic blood pressure (SBP) time in target range (TTR) and cardiovascular events. Results indicated that 100% TTR <140 mm Hg was associated with a 19% reduced risk of cardiovascular disease (CVD) and 100% TTR <130 mm Hg was linked to a 28% reduced risk of major adverse cardiovascular events (MACE).
Key findings
- 100% TTR <140 mm Hg was associated with a 19% reduced risk of CVD (HR, 0.81; P = .01).
- 100% TTR <130 mm Hg was linked to a 28% reduced risk of MACE (HR, 0.72; P < .01).
- Associations were strongest among women and frail/pre-frail participants.
- Findings remained consistent after adjusting for competing risks and extending the TTR estimation period.
Why it matters
The study highlights the significance of maintaining optimal blood pressure control in older adults, as prolonged time in target range is associated with lower risks of cardiovascular events, which is crucial for improving health outcomes in this population.