Identification of risk factors for hospital-onset bacteraemia to inform a routine data based risk prediction: an umbrella review.

In 30 seconds

This umbrella review identified and classified risk factors for hospital-onset bacteraemia (HOB) in OECD countries. The study synthesized evidence from 19 systematic reviews, revealing 43 risk factors, including prior bloodstream infection (OR = 6.56) and male sex (OR = 2.18). The findings aim to inform risk prediction models for infection prevention.

Key findings

• Prior bloodstream infection was associated with an odds ratio of 6.56 for HOB.
• Male sex had an odds ratio of 2.18, indicating increased risk.
• Multiple comorbidities were linked to an odds ratio of 1.66.
• Red blood cell transfusion was associated with a risk ratio of 4.82.

Why it matters

Understanding the risk factors for hospital-onset bacteraemia is essential for developing effective infection prevention strategies. Identifying high-risk patients can lead to targeted interventions that may reduce morbidity and mortality associated with HOB.