Trough-to-peak ratios and elimination half-lives of antihypertensive drugs: implications for 24-hour blood pressure control in primary care.
Aten PrimariaJul 3, 2026 (epub)
Mar Serrat-Costa, Gabriel Coll de Tuero, Ernest Vinyoles Bargalló et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review compiled trough-to-peak (TP) ratios and elimination half-lives of 83 antihypertensive drugs from 228 publications. It found substantial variability in TP ratios and half-lives across different pharmacological classes. The findings aim to enhance understanding of 24-hour blood pressure control and inform treatment selection in clinical practice.
Key findings
- TP ratios were available for 69 antihypertensive drugs.
- Elimination half-life values were reported for 77 antihypertensive drugs.
- Substantial variability in TP ratios and half-lives was observed across pharmacological classes.
Why it matters
Understanding the pharmacokinetics of antihypertensive medications is crucial for optimizing 24-hour blood pressure control, which can improve patient outcomes and guide treatment decisions in primary care.