The co-existence of Ehlers-Danlos syndrome and postural orthostatic tachycardia syndrome: A systematic review of the literature.
Auton NeurosciJun 27, 2026 (epub)
Chun Shing Kwok, Georgia Hagger, David Gillespie et al.
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In 30 seconds
This systematic review evaluated the co-existence of Ehlers-Danlos syndrome (EDS) and postural orthostatic tachycardia syndrome (POTS) across 30 studies involving 8421 EDS patients and 12,983 POTS patients. The prevalence of POTS in EDS patients ranged from 17.5% to 92.7%, while EDS in POTS patients ranged from 17.9% to 50.0%.
Key findings
- POTS prevalence in EDS patients ranges from 17.5% to 92.7%, depending on the population.
- EDS prevalence in POTS patients ranges from 17.9% to 50.0%, varying by population.
- Patients with both EDS and POTS reported greater medication use and more clinic visits compared to those with POTS alone.
- Increased gastrointestinal symptoms were noted in patients with both conditions, particularly postprandial distress syndrome.
Why it matters
Understanding the co-occurrence of EDS and POTS is crucial for clinicians, as it may influence treatment strategies and patient management, particularly regarding symptom management and medication use.