Measurement of low-density lipoprotein cholesterol and other circulating lipids in Brazil: a systematic literature review.
Clin Chim ActaJul 4, 2026 (epub)
David G A Conti, Livia Souza Tosetti, Fernando Jablonka et al.
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In 30 seconds
This systematic review evaluates laboratory methods for measuring circulating lipids in Brazil, focusing on LDL-C estimation formulas. It analyzes 25 studies and finds that the Martin/Hopkins formula categorizes LDL-C more accurately than Friedewald (89.6% vs 83.2% correct categorization) in a large patient population. The review emphasizes the need for standardized lipid assessment practices in Brazil.
Key findings
- Martin/Hopkins formula shows 89.6% correct categorization for LDL-C compared to Friedewald's 83.2%.
- Enzymatic colorimetric assays are the standard for measuring triglycerides, total cholesterol, and HDL-C.
- Direct measurement of LDL-C is recommended only for triglyceride levels beyond the validated range.
- Nationally derived reference intervals are needed for equitable cardiovascular risk assessment in Brazil.
Why it matters
Accurate lipid measurement and interpretation are crucial for effective cardiovascular risk stratification. This review highlights the importance of using appropriate formulas and standardization in clinical practice to improve patient outcomes.