Impact of creatine supplementation alone or combined with exercise on inflammatory and clinical outcomes in chronic musculoskeletal pain treated in the rheumatological field: a systematic review.
Joaquín Salazar-Méndez, Rodrigo Núñez-Cortés, Cristian Salazar-Orellana et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review evaluated the effects of creatine supplementation, alone or with exercise, on inflammatory and clinical outcomes in individuals with chronic musculoskeletal pain. Eight studies involving 189 participants were analyzed, revealing that combined creatine and resistance training may enhance muscle strength, skeletal muscle mass, and quality of life in osteoarthritis patients. However, evidence on pain relief and inflammation is limited.
Key findings
- Combined creatine and resistance training may improve muscle strength and quality of life in osteoarthritis patients.
- Fibromyalgia studies showed increased muscle strength but inconsistent effects on pain.
- Rheumatoid arthritis trials indicated gains in skeletal muscle mass and potential reductions in disease activity.
- No major adverse events were reported from creatine supplementation.
Why it matters
Understanding the potential benefits of creatine supplementation in conjunction with exercise could inform treatment strategies for chronic musculoskeletal pain, particularly in rheumatological conditions. This may enhance patient outcomes in terms of strength and quality of life.