International study of coronary microvascular angina (iCorMicA): A registry-based diagnostic study and nested randomized trial.
Am Heart JJul 6, 2026 (epub)
Clinical ResearchCardiology
Daniel Ang, Robin Young, Diann Taggart et al.
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In 30 seconds
The iCorMicA study is an international, multicenter, registry-based diagnostic study and nested randomized trial assessing causes of angina in patients with no obstructive coronary artery disease. It enrolled 1,483 participants, with 1,047 randomized. The primary outcome is the change in Seattle Angina Questionnaire summary score at 12 months, aiming to provide insights into angina management.
Key findings
- 1,483 participants were enrolled in the registry, with 1,047 randomized.
- The primary outcome measures the change in Seattle Angina Questionnaire score at 12 months.
- Participants with abnormal index of microcirculatory resistance (IMR) and coronary flow reserve (CFR) were assessed.
Why it matters
Understanding the causes and management of angina in patients without obstructive coronary artery disease is crucial, particularly as this condition disproportionately affects women. Improved diagnostic and therapeutic strategies could enhance patient outcomes.