Molecular epidemiology of Mycobacterium tuberculosis in the Middle East and North Africa: A systematic review and meta-analysis.
Int J Infect DisJul 8, 2026 (epub)
Clinical ResearchInfectious Diseases
Tsegaye Shamebo, Aboma Zewude, Temesgen Mohammed et al.
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In 30 seconds
This systematic review and meta-analysis examined the molecular epidemiology of Mycobacterium tuberculosis in the Middle East and North Africa, analyzing 13,194 isolates from 59 studies. The findings revealed a clustering rate of 52% and a recent transmission index of 40%, indicating ongoing transmission of tuberculosis in the region.
Key findings
- The clustering rate of Mycobacterium tuberculosis was 52% (95% CI: 43-61%).
- The recent transmission index was found to be 40% (95% CI: 33-47%).
- Lineages 4 and 3 were the most prevalent, accounting for 42.3% and 28.3% of isolates, respectively.
- Clustering rates varied significantly based on genotyping methods used.
Why it matters
Understanding the molecular epidemiology of tuberculosis is crucial for developing effective public health strategies. The high clustering rate and recent transmission index suggest that tuberculosis control measures need to be enhanced to prevent further spread.